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IMMUNE CHECKPOINTS AND 
MEDULLOBLASTOMA

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BRL course period 3 2020-2021
BRL course period 3 2020-2021

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ABSTRACT


Medulloblastomas and CNS embryonal tumors are highly malignant brain tumors that predominantly occur in young infants. Current standard therapy includes surgery followed by irradiation and chemotherapy. However, these tumors often relapse and appropriate treatment for these relapsed tumors is a huge clinical problem. Immunotherapy to boost the immune system is emerging as a novel promising approach in clinical trials. However, immunotherapy is often hampered by inhibitory immune receptors (immune checkpoints) on both immune cells and the tumor. Targeting and relief of this immune-inhibitory break currently is a promising new therapeutic approach in many cancers, including melanoma and lung cancer. The expression profile of immune checkpoints in pediatric human CNS embryonal tumors and medulloblastomas currently remains unknown.


 

EXPERTS INVOLVED
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PROF. DR. PIETER WESSELING

Neuropathologist

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DR. FRISO CALKOEN

Pediatric oncologist

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DR. JASPER VAN DER LUGT

Pediatric oncologist